Copyright ©2011 Baishideng Publishing Group Co.
World J Hepatol. Jan 27, 2011; 3(1): 1-7
Published online Jan 27, 2011. doi: 10.4254/wjh.v3.i1.1
Figure 1
Figure 1 Regulation of T cell activation by cytotoxic T lymphocyte antigen 4. While cytotoxic T lymphocyte antigen 4 (CTLA-4) is constitutively expressed on regulatory T cells (Tregs), its expression is induced on effector T cells (Teff) upon activation. While it is well-established that CTLA-4 is required for the optimal function of Tregs, its role on natural killer T cells or effector T cells is less clear. DCs: dentritic cells; NKT: natural killer T; GSLs: glycosphingolipids.