Liver disease epidemiology and burden in patients with alterations in plasma protein metabolism: German retrospective insurance claims analysis

Figure 1 Selection of patient cohorts. ¹In total, 135 patients had only one outpatient alterations in plasma protein metabolism (APPM) diagnosis and therefore did not meet these criteria; ²In total, 42 patients with fibrosis in the APPM cohort progressed to cirrhosis during follow-up; and ³In total, 280 patients with fibrosis in the control cohort progressed to cirrhosis during follow-up. ICD-10-GM: German Modification of the International Classification of Diseases-10^th Revision.

Figure 2 Disease progression events. Disease progression events that occurred after the index date until the end of the study. APPM: Alterations in plasma protein metabolism.

Figure 3 Event-free survival for disease progression events in patients with cirrhosis with and without alterations in plasma protein metabolism. A: Ascites; B: Hepatic failure; C: Esophageal and gastric varices; D: Hepatic encephalopathy. APPM: Alterations in plasma protein metabolism; CI: Confidence interval; NR: Not reached.

Figure 4 Survival in patients with fibrosis and cirrhosis. A: Fibrosis; B: Cirrhosis. APPM: Alterations in plasma protein metabolism; CI: Confidence interval; NR: Not reached.