Prospective Study
Copyright ©The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Hepatol. Mar 8, 2017; 9(7): 401-408
Published online Mar 8, 2017. doi: 10.4254/wjh.v9.i7.401
Phase angle obtained by bioelectrical impedance analysis independently predicts mortality in patients with cirrhosis
Giliane Belarmino, Maria Cristina Gonzalez, Raquel S Torrinhas, Priscila Sala, Wellington Andraus, Luiz Augusto Carneiro D’Albuquerque, Rosa Maria R Pereira, Valéria F Caparbo, Graziela R Ravacci, Lucas Damiani, Steven B Heymsfield, Dan L Waitzberg
Giliane Belarmino, Raquel S Torrinhas, Priscila Sala, Wellington Andraus, Luiz Augusto Carneiro D’Albuquerque, Graziela R Ravacci, Dan L Waitzberg, Department of Gastroenterology, Surgical Division, Faculdade de Medicina da Universidade de São Paulo, Sao Paulo 05403-000, Brazil
Maria Cristina Gonzalez, Postgraduate Program in Health and Behavior, Universidade Católica de Pelotas, Pelotas 96015-560, Brazil
Maria Cristina Gonzalez, Steven B Heymsfield, Pennington Biomedical Research Center, Baton Rouge, LA 70808, United States
Rosa Maria R Pereira, Valéria F Caparbo, Laboratory of Bone Metabolism, Rheumatology Division, Faculdade de Medicina da Universidade de São Paulo, São Paulo 05403-000, Brazil
Lucas Damiani, Research Institute, Hospital do Coração de São Paulo, São Paulo 04004-030, Brazil
Author contributions: Belarmino G, Gonzalez MC, Waitzberg DL, Heymsfield SB, Pereira RMR and D’Albuquerque LAC contributed to the conception and design and/or coordination of the study; Belarmino G, Gonzalez MC, Torrinhas RS, Waitzberg DL, Sala P, Andraus W, Heymsfield SB and Caparbo VF were responsible for the acquisition, analysis, and/or interpretation and discussion of data; Belarmino G, Torrinhas RS, Gonzalez MC and Ravacci GR drafted the manuscript; Damiani L performed statistical analyses; all authors read and approved the final manuscript.
Supported by The Fundação de Amparo à Pesquisa do Estado de São Paulo, Nos. 2011/13243-3, 2012/15677-3 [GB].
Institutional review board statement: The study was reviewed and approved by the Institutional Ethics Review Board (0646/11) of the Hospital das Clínicas (São Paulo, SP, Brazil).
Clinical trial registration statement: This clinical trial was registered at ClinicalTrials.gov with the identifier NCT02421848. Details can be found at https://clinicaltrials.gov/ct2/show/NCT02421848.
Informed consent statement: All study participants, or their legal guardians, provided written consent prior to study enrollment.
Conflict-of-interest statement: The authors of this manuscript have no conflict of interest to disclose.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Dr. Giliane Belarmino, Department of Gastroenterology, Surgical Division, Faculdade de Medicina da Universidade de São Paulo, Avenida Dr. Arnaldo, 455, Cerqueira César, Sao Paulo 05403-000, Brazil. giliane85@hotmail.com
Telephone: +55-11-30617459 Fax: +55-11-30617459
Received: July 30, 2016
Peer-review started: August 2, 2016
First decision: September 8, 2016
Revised: December 22, 2016
Accepted: January 11, 2017
Article in press: January 14, 2017
Published online: March 8, 2017
Core Tip

Core tip: This article provides original data displaying the good performance of the phase angle (PA) obtained by bioelectrical impedance analysis in the evaluation of mortality prognosis in patients with cirrhosis. The findings suggest that the PA is a safe, practical, and inexpensive tool for the prediction of mortality potentially associated with malnutrition.