Published online Mar 8, 2017. doi: 10.4254/wjh.v9.i7.349
Peer-review started: December 25, 2016
First decision: January 16, 2017
Revised: January 17, 2017
Accepted: February 8, 2017
Article in press: February 13, 2017
Published online: March 8, 2017
Core tip: A large number of studies have found that the impaired Parkin function or downregulation of expression may induce cancer initiation and progression via mitophagy-related/unrelated mechanisms. Thus, there is a growing belief that Parkin may have tumor suppressor effects. Based on literature and on the authors’ recent publications regarding animal models of alcohol abuse, this paper highlights the various roles of Parkin in the suppression of oncogenesis. Proper understanding of Parkin functions may have therapeutic implications in the treatment of various cancers.