Published online Feb 28, 2017. doi: 10.4254/wjh.v9.i6.293
Peer-review started: October 2, 2016
First decision: October 20, 2016
Revised: December 30, 2016
Accepted: February 8, 2017
Article in press: February 13, 2017
Published online: February 28, 2017
Core tip: Hepatorenal syndrome (HRS) is a life-threatening complication present in very advanced liver cirrhosis. This manuscript addresses many recent advances in this field, including the recent change in the definition of HRS according to acute kidney injury criteria, the potential consequences of the adoption of this new definition, and the use of biomarkers to help in the diagnostic algorithm. Moreover, it reviews the recent advances in treatment of HRS such as the use of continuous infusion of terlipressin instead of bolus and the low efficacy of midodrine plus octreotide. Potential areas of research are identified as well.