Basic Study
Copyright ©The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Hepatol. Feb 8, 2017; 9(4): 209-216
Published online Feb 8, 2017. doi: 10.4254/wjh.v9.i4.209
Antioxidant effects of aqueous extract of Salep on Paraquat-induced rat liver injury
Shekoufeh Atashpour, Hossein Kargar Jahromi, Zahra Kargar Jahromi, Sanaz Zarei
Shekoufeh Atashpour, 2nd Department of Pharmacology, Jahrom University of Medical Sciences, Jahrom 7414846192, Iran
Shekoufeh Atashpour, Hossein Kargar Jahromi, Research Center for Non-Communicable Disease, Jahrom University of Medical Sciences, Jahrom 7414846192, Iran
Hossein Kargar Jahromi, 2nd Zoonoses Research Center, Jahrom University of Medical Sciences, Jahrom 7414846192, Iran
Zahra Kargar Jahromi, Zoonoses Research Center, Jahrom University of Medical Sciences, Jahrom 7414846192, Iran
Sanaz Zarei, Student Research Committee, Jahrom University of Medical Sciences, Jahrom 7414846192, Iran
Author contributions: Atashpour S designed the study and wrote the paper; Kargar Jahromi H designed and performed the study; Kargar Jahromi Z performed the study; all authors drafted the article and made critical revisions related to the intellectual content of the manuscript, and approved the final version of the article to be published.
Supported by The results described in this article are part of a Medical student, Sanaz Zarei’s dissertation that was financially supported by Jahrom University of Medical Sciences, Jahrom, Iran.
Institutional review board statement: The study was reviewed and approved by Research Center for Non-Communicable Diseases, Jahrom University of Medical Sciences, Jahrom, Iran.
Institutional animal care and use committee statement: All procedures involving animals were reviewed and approved by the Institutional Animal Care and Use Committee of the (Jahrom University of Medical Sciences) (IACUC Protocol Number: IR.JUMS.1394.722).
Conflict-of-interest statement: To the best of our knowledge, no conflict of interest exists.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Hossein Kargar Jahromi, PhD, Research Center for Non-Communicable Diseases, Jahrom University of Medical Sciences, Shahid Motahari Street, Jahrom 7414846192, Iran. hossein.kargarjahromy@yahoo.com
Telephone: +98-71-54340405 Fax: +98-71-54340405
Received: July 21, 2016
Peer-review started: July 22, 2016
First decision: September 5, 2016
Revised: November 6, 2016
Accepted: December 13, 2016
Article in press: December 14, 2016
Published online: February 8, 2017
Core Tip

Core tip: Oxidative stress has a key role in triggering Paraquat-mediated liver injury. Paraquat causes oxidative stress via modulation of redox cycling, generation of free radicals and reduction of endogenous antioxidant levels. Salep from orchid family (Orchidaceae) used in traditional medicine as a healing agent in the treatment of breast disorders, gastrointestinal disorders, tuberculosis, diarrhea, Parkinson, cancer, fever, and impotency. Salep is used in food engineering for preparation of ice cream and drinks. This study showed that Salep could have a protective effect against Paraquat-induced hepatic injury via reinforcing endogenous antioxidant systems, reduction of lipid peroxidation and free radical scavenging. The antioxidant and protective effect of Salep could be due to presence of flavonoids and polyphenols such as Quercetin, Ferulic Acid and Glucomannan.