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©The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Hepatol. Jan 28, 2017; 9(3): 131-138
Published online Jan 28, 2017. doi: 10.4254/wjh.v9.i3.131
Published online Jan 28, 2017. doi: 10.4254/wjh.v9.i3.131
Cockcroft-Gault revisited: New de-liver-ance on recommendations for use in cirrhosis
Gianni B Scappaticci, Department of Pharmacy Services, University of Michigan Health System and College of Pharmacy, Ann Arbor, MI 48109-2054, United States
Randolph E Regal, Department of Pharmacy Services, Adult Internal Medicine/Gastroenterology, University of Michigan Health System and College of Pharmacy, Ann Arbor, MI 48109-2054, United States
Author contributions: Scappaticci GB performed the majority of the writing, prepared the figures and tables; Regal RE designed the outline, coordinated the writing of the paper, provided input and feedback, and contributed to writing.
Conflict-of-interest statement: Both authors do not have any conflicts to disclose regarding the content of this manuscript.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Gianni B Scappaticci, PharmD, PGY1 Pharmacy Resident/Adjunct Clinical Instructor, Department of Pharmacy Services, University of Michigan Health System and College of Pharmacy, 1111 E. Catherine Street, Ann Arbor, MI 48109-2054, United States. gbscapp@med.umich.edu
Telephone: +1-734-7647007 Fax: +1-734-6152314
Received: August 21, 2016
Peer-review started: August 23, 2016
First decision: October 28, 2016
Revised: November 11, 2016
Accepted: December 13, 2016
Article in press: December 14, 2016
Published online: January 28, 2017
Peer-review started: August 23, 2016
First decision: October 28, 2016
Revised: November 11, 2016
Accepted: December 13, 2016
Article in press: December 14, 2016
Published online: January 28, 2017
Core Tip
Core tip: For many health care professionals in the United States, the Cockcroft-Gault (CG) equation has become perhaps the most popular practical approach for estimating renal function. Despite its widespread use, clinicians often overlook not only the limitations of the original serum creatinine (SCr) based equation, but also may not appreciate the validity of variations used to compensate for these limitations. For cirrhotic patients in particular, the underlying disease pathophysiology contributes to a falsely low SCr, thereby overestimating renal function with use of the CG equation in this population.