Copyright
©The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Hepatol. Oct 8, 2017; 9(28): 1133-1140
Published online Oct 8, 2017. doi: 10.4254/wjh.v9.i28.1133
Published online Oct 8, 2017. doi: 10.4254/wjh.v9.i28.1133
Acute-on-chronic liver failure in a multi-ethnic Asian city: A comparison of patients identified by Asia-Pacific Association for the Study of the Liver and European Association for the Study of the Liver definitions
Anandraj Selva Rajoo, Seng-Gee Lim, Yock-Young Dan, Guan-Huei Lee, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 119077, Singapore
Seng-Gee Lim, Institute of Molecular and Cell Biology, ASTAR, Singapore 138668, Singapore
Seng-Gee Lim, Wah Wah Phyo, Yock-Young Dan, Yin-Mei Lee, How-Cheng Low, Kieron Lim, Poh-Seng Tan, Guan-Huei Lee, Division of Gastroenterology and Hepatology, Department of Medicine, National University Hospital, Singapore 119228, Singapore
Thandar Tun, Department of Hepatology, Mandalay General Hospital, 30th St, Chan Aye Tharsan Township, Mandalay, Myanmar
Author contributions: Lee GH contributed to study conception and design; Selva Rajoo A, Lim SG, Phyo WW, Tun T, Dan YY, Lee YM, Low HC, Lim K, Tan PS and Lee GH contributed to data acquisition, data analysis, and interpretation; Selva Rajoo A contributed to the writing of the article; Lim SG and Lee GH contributed to editing, reviewing and final approval of the article.
Institutional review board statement: The study was reviewed and approved by the National Healthcare Group Domain Specific Research Board.
Informed consent statement: Informed consent has been obtained from all eligible patients who can provide informed consent.
Conflict-of-interest statement: There are no existing or potential conflicts of interest for any of the investigators participating in this study and their immediate family members.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Guan-Huei Lee, MBBS, FRCP (Edin), PhD, Division of Gastroenterology and Hepatology, Department of Medicine, National University Hospital, 1E Kent Ridge Road, NUHS Tower Block, Singapore 119228, Singapore. mdcleegh@nus.edu.sg
Telephone: +65-67725595 Fax: +65-67751518
Received: January 4, 2017
Peer-review started: January 7, 2017
First decision: March 13, 2017
Revised: July 23, 2017
Accepted: September 14, 2017
Article in press: September 15, 2017
Published online: October 8, 2017
Peer-review started: January 7, 2017
First decision: March 13, 2017
Revised: July 23, 2017
Accepted: September 14, 2017
Article in press: September 15, 2017
Published online: October 8, 2017
Core Tip
Core tip: Acute-on-chronic liver failure (ACLF) is a distinct disease entity with a high short-term mortality. Utilizing both the Asia-Pacific Association for the Study of the Liver (APASL) and European Association for the Study of the Liver criteria, our study shows that the clinical profile of ACLF patients in Singapore appears to have mixed features compared with similar studies reported in the rest of Asia and the West. Patients with ACLF fulfilling only the APASL criteria in our study had significantly better survival rates. We also analyzed the prognostic factors of ACLF in our study.