Published online Sep 8, 2017. doi: 10.4254/wjh.v9.i25.1043
Peer-review started: June 1, 2017
First decision: July 11, 2017
Revised: July 20, 2017
Accepted: August 3, 2017
Article in press: August 4, 2017
Published online: September 8, 2017
Core tip: Despite the increasing awareness regarding the issue of hepatitis B virus reactivation (HBVr) in patients undergoing immunosuppressive treatments, there are still some many debated items concerning this potentially fatal but preventable complication. Both hepatitis B surface antigen (HBsAg) patients and subjects with serological signs of previous resolved exposure to the virus (HBsAg negative/anti-core antibody positive patients) are at risk of HBVr. Purpose of our work was to analyze the current international literature and dedicate guidelines, providing evidences and strategies that have been proposed to manage these patients.