Published online Jul 8, 2017. doi: 10.4254/wjh.v9.i19.833
Peer-review started: February 7, 2017
First decision: March 28, 2017
Revised: April 13, 2017
Accepted: May 3, 2017
Article in press: May 5, 2017
Published online: July 8, 2017
Core tip: Advances in the understanding of the molecular biology of hepatitis C virus (HCV) have ushered in a new era in treatment. Recent studies have shifted the focus to the more difficult-to-treat cohorts of patients. The presence of chronic kidney disease and end stage renal disease were exclusion criteria for the pivotal clinical direct-acting antiviral agents trials, creating a group of patients with a large unmet medical need. This review will update the reader on the use of the direct acting antiviral agents in the HCV-infected patient with kidney disease. Recommendations for the timing of therapy, choice of agents and management of the kidney transplant candidate will be presented.