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World J Hepatol. May 8, 2017; 9(13): 627-634
Published online May 8, 2017. doi: 10.4254/wjh.v9.i13.627
Management of centrally located hepatocellular carcinoma: Update 2016
Wei-Bo Yu, Andrew Rao, Victor Vu, Lily Xu, Jian-Yu Rao, Jian-Xiong Wu
Wei-Bo Yu, Victor Vu, Jian-Yu Rao, Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA 90095, United States
Andrew Rao, the College of Letters and Science, University of California at Davis, Davis, CA 95616, United States
Lily Xu, Chemistry Department, Wellesley College, Wellesley, MA 02481, United States
Jian-Xiong Wu, Department of Hepatobiliary Surgery, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China
Author contributions: Yu WB and Wu JX designed the aim of this review; Yu WB, Rao A and Rao JY prepared the manuscript; Vu V and Xu L critically reviewed the manuscript.
Conflict-of-interest statement: All authors have no conflict of interest.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Jian-Xiong Wu, MD, Professor, Chief, Department of Hepatobiliary Surgery, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, 17 Panjiayuan Nanli, Beijing 100021, China. dr.wujx@hotmail.com
Telephone: +86-10-87787100
Received: January 27, 2017
Peer-review started: February 12, 2017
First decision: March 8, 2017
Revised: March 24, 2017
Accepted: April 6, 2017
Article in press: April 10, 2017
Published online: May 8, 2017
Core Tip

Core tip: Centrally located hepatocellular carcinoma (HCC) is situated in the deeper portions of the liver and adjoins main vascular structures. Due to this special location, the management of this group of patients is challenging. Low resection rates and high recurrence rates are two major problems that urgently need to be resolved. This review summarizes the evolution of our understanding for centrally located HCC and the development of disease management, and explores the possible strategies to improve overall patient survival.