Published online May 8, 2017. doi: 10.4254/wjh.v9.i13.613
Peer-review started: March 7, 2017
First decision: March 27, 2017
Revised: April 1, 2017
Accepted: April 23, 2017
Article in press: April 24, 2017
Published online: May 8, 2017
Core tip: The therapeutic options for inflammatory bowel disease (IBD) are expanding, and the number of drugs will rapidly increase in coming years. The fear of side effects represents one the most limiting factor of their use. Despite a widespread use for years, drug induced liver injury (DILI) management remains a challenging situation with Azathioprine and Methotrexate. DILI seems less frequent with anti-tumor necrosis factor agents and new biologic therapies. The aim of this review is to report incidence, physiopathology and practical guidelines in case of DILI occurrence with the armamentarium of old and new drugs in the field of IBD.