Published online Mar 28, 2016. doi: 10.4254/wjh.v8.i9.421
Peer-review started: May 7, 2015
First decision: September 8, 2015
Revised: March 6, 2016
Accepted: March 14, 2016
Article in press: March 16, 2016
Published online: March 28, 2016
Core tip: Liver cancer is the fifth leading cause of cancer worldwide, and the third-leading cause of cancer death. Altouhg some risk factors have been classically associated with development of hepatocellular carcinoma (HCC), in the last years, also, some protective factors have been described, like coffee drink, and drugs like statins and beta-blockers. The current European Association for the Study of Liver and American Association for the Study of Liver Diseases guidelines recomended the barcelona clinic liver cancer classification as staging system for prognosis prediction and treatment allocation The therapeutic approach in patients with HCC depends on factors such as liver function, tumour extension and comorbidities existence. Available treatments are: Surgical treatments, percutaneous ablation, chemoembolization, radioembolization and systemic treatment.