Retrospective Study
Copyright ©The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Hepatol. Oct 28, 2016; 8(30): 1269-1278
Published online Oct 28, 2016. doi: 10.4254/wjh.v8.i30.1269
Retrospective study of the associations between hepatitis C virus infection and metabolic factors
Shira Yair-Sabag, Elchanan Nussinson, Ofir Ben-Assuli, Fahmi Shibli, Azmi Shahbari, Shira Zelber-Sagi
Shira Yair-Sabag, Elchanan Nussinson, Fahmi Shibli, Azmi Shahbari, Gastroenterology Institute, Emek Medical Center, Afula 18742, Israel
Shira Yair-Sabag, Shira Zelber-Sagi, School of Public Health, University of Haifa, Haifa 3498838, Israel
Ofir Ben-Assuli, Ono Academic College, Kiryat Ono 5545173, Israel
Author contributions: Yair-Sabag S performed the research and drafted and wrote the paper; Yair-Sabag S, Nussinson E and Zelber-Sagi S contributed equally to this manuscript; Nussinson E wrote the paper and supervised the study; Ben-Assuli O provided analytical oversight; Shibli F and Shahbari A provided administrative support; Zelber-Sagi S designed and supervised the study.
Institutional review board statement: This study was reviewed and approved by the Haifa University and Emek Medical Center Institutional Review Boards.
Informed consent statement: All study participants provided verbal informed consent prior to study enrollment.
Conflict-of-interest statement: There are no conflicts of interest to declare.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See:
Correspondence to: Elchanan Nussinson, MD, Gastroenterology Institute, Emek Medical Center, Duchifat 7 St, Afula 18742, Israel.
Telephone: +972-54-4943922 Fax: +972-4-6523745
Received: May 8, 2016
Peer-review started: May 9, 2016
First decision: June 13, 2016
Revised: July 28, 2016
Accepted: September 13, 2016
Article in press: September 18, 2016
Published online: October 28, 2016
Core Tip

Core tip: Hepatitis C virus (HCV) is associated with a unique metabolic syndrome (MS) type: Insulin resistance with type 2 diabetes mellitus (T2DM), hypocholesterolemia, and liver steatosis. We retrospectively investigated the association between MS components and HCV infection, including antiviral therapy response, for 119 patients infected with HCV treated with interferon alpha and ribavirin. After long-term follow-up, de novo T2DM incidence significantly decreased, and triglyceride levels significantly increased in treatment responders. Only steatosis tended to affect treatment response. The association between HCV and lipid metabolic pathways may be important even with new direct antiviral agents. Patients infected with HCV should be screened for T2DM.