Published online Jan 28, 2016. doi: 10.4254/wjh.v8.i3.139
Peer-review started: May 8, 2015
First decision: September 8, 2015
Revised: December 15, 2015
Accepted: January 5, 2016
Article in press: January 7, 2016
Published online: January 28, 2016
Core tip: Treatment of chronic hepatitis C virus (HCV) infections has undergone a revolutionary change in recent years. This review highlights the current state of the art of antiviral treatment in chronic hepatitis C infections and gives an outlook for upcoming therapies. Difficult to treat populations such as patients with decompensated liver cirrhosis, HCV-human immunodeficiency virus co-infections, after liver transplantation and patients with renal impairment or on hemodialysis are highlighted.