Published online Oct 8, 2016. doi: 10.4254/wjh.v8.i28.1157
Peer-review started: March 7, 2016
First decision: April 15, 2016
Revised: July 22, 2016
Accepted: August 6, 2016
Article in press: August 8, 2016
Published online: October 8, 2016
Core tip: In chronic liver disease, including autoimmune liver diseases, perpetual liver injury leads to persistent inflammation, cell proliferation and the deposition of extracellular matrix proteins. If left untreated, this process eventually leads to the development of liver cirrhosis, characterised by the presence of fibrosis and nodular regeneration. Liver biopsy is currently the gold standard technique, but highly promising non-invasive methodology is under development.