Published online Jan 18, 2016. doi: 10.4254/wjh.v8.i2.131
Peer-review started: July 11, 2015
First decision: September 16, 2015
Revised: December 10, 2015
Accepted: December 29, 2015
Article in press: January 4, 2016
Published online: January 18, 2016
Core tip: Chronic hepatitis C virus (HCV) infection is associated with a higher prevalence of diabetes as compared to either the general population or patients with chronic hepatitis B infections. HCV hepatitis is linked to insulin resistance (IR) early in the disease course, mediated partly by direct inhibitory effect of the viral proteins on insulin signaling. The presence of IR is associated with an increased rate of disease progression to fibrosis, cirrhosis and hepatocellular carcinoma. Interferon and ribavirin treatment of HCV hepatitis may be less successful in the presence of IR. The effect of IR on the new direct-acting antiviral treatment is unclear.