Published online May 18, 2016. doi: 10.4254/wjh.v8.i14.607
Peer-review started: January 22, 2016
First decision: March 1, 2016
Revised: March 14, 2016
Accepted: April 21, 2016
Article in press: April 22, 2016
Published online: May 18, 2016
Core tip: Trans-catheter arterial chemoembolization (TACE) is recommended as the standard treatment of intermediate hepatocellular carcinoma (HCC) by the Barcelona Clinic Liver Cancer guideline, and this review investigates whether liver resection is better than TACE for intermediate HCC. Based on published studies, we compare the survival benefits and complications of liver resection and TACE for intermediate HCC. We also compare the survival benefits of liver resection in early and intermediate HCC. We find that liver resection could achieve better or at least comparable survival outcomes compared with TACE for intermediate HCC; however, we do not observe a significant difference between liver resection and TACE in terms of safety and morbidity.