Copyright
©The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
Chaperones in hepatitis C virus infection
Ronik Khachatoorian, Samuel W French, Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at University of California, Los Angeles, CA 90095, United States
Samuel W French, Jonsson Comprehensive Cancer Center, David Geffen School of Medicine at University of California, Los Angeles, CA 90095, United States
Samuel W French, UCLA AIDS Institute, David Geffen School of Medicine at University of California, Los Angeles, CA 90024, United States
Author contributions: Khachatoorian R conducted an extensive article search, identified all relevant articles, developed the outline of the review article, prepared all the drafts, revised the accepted manuscript, and approved the article to be published; French SW contributed to the design and writing of the manuscript, reviewed and edited the drafts, revised the accepted manuscript, and approved the article to be published.
Supported by NIH R01DK090794, SWF.
Conflict-of-interest statement: The authors declare no conflict of interest.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Samuel W French, MD, PhD, Associate Professor, Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at University of California, 10833 Le Conte Avenue, Los Angeles, CA 90095, United States. sfrench@mednet.ucla.edu
Telephone: +1-310-2672795 Fax: +1-310-2672058
Received: April 29, 2015
Peer-review started: May 7, 2015
First decision: September 8, 2015
Revised: October 1, 2015
Accepted: December 17, 2015
Article in press: December 18, 2015
Published online: January 8, 2016
Peer-review started: May 7, 2015
First decision: September 8, 2015
Revised: October 1, 2015
Accepted: December 17, 2015
Article in press: December 18, 2015
Published online: January 8, 2016
Core Tip
Core tip: Interaction of viral proteins with host chaperones is critical for the hepatitis C viral (HCV) life cycle. Some of these chaperones, such as cyclophilins have been studied in detail recently and have led to the advent of new therapies for HCV infection with high success rates. Further investigation of the role of chaperones in the viral life cycle may allow for development of novel therapies both for HCV and related viruses.