Copyright
©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Hepatol. May 8, 2015; 7(7): 968-979
Published online May 8, 2015. doi: 10.4254/wjh.v7.i7.968
Published online May 8, 2015. doi: 10.4254/wjh.v7.i7.968
Control of oxidative stress in hepatocellular carcinoma: Helpful or harmful?
Akinobu Takaki, Kazuhide Yamamoto, Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Kita-ku, Okayama 700-8558, Japan
Author contributions: Takaki A designed and wrote this article; Yamamoto K contributed equally to this work by providing reviews and guidance.
Conflict-of-interest: The authors declare no conflicts of interest regarding this manuscript.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Akinobu Takaki, MD, Associate Professor, Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Kita-ku, Okayama 700-8558, Japan. akitaka@md.okayama-u.ac.jp
Telephone: +81-86-2357219 Fax: +81-86-2255991
Received: August 28, 2014
Peer-review started: August 31, 2014
First decision: November 14, 2014
Revised: January 21, 2015
Accepted: January 30, 2015
Article in press: February 2, 2015
Published online: May 8, 2015
Peer-review started: August 31, 2014
First decision: November 14, 2014
Revised: January 21, 2015
Accepted: January 30, 2015
Article in press: February 2, 2015
Published online: May 8, 2015
Core Tip
Core tip: Oxidative stress is a key biological response that correlates with the progression of chronic liver disease. However, oxidative stress is an essential survival mechanism and thus to erase it is an unsuitable approach to disease control. As hepatocarcinogenesis is closely associated with increased oxidative stress via viral proteins or chronic inflammation and lipids, controlling oxidative stress should be effective against progressive liver disease. Agents that can control oxidative stress might represent a more effective approach than reactive oxygen species-scavenging agents.