Published online Apr 18, 2015. doi: 10.4254/wjh.v7.i5.761
Peer-review started: August 30, 2014
First decision: November 19, 2014
Revised: November 26, 2014
Accepted: December 16, 2014
Article in press: December 17, 2014
Published online: April 18, 2015
Core tip: Due to immunesuppresive effect of uremia and dialyser membranes, chronicity of hepatitis B virus (HBV) infection is frequently observed. Rates of seroconversion induced by HBV vaccine is diminished in chronic kidney disease patients when compared to the general population, which gradually decrease as renal functions deteriorates. Efficient dialysis is a major determinant of response to HBV vaccination. In contrast to three doses of 20 μg HBV vaccine for the general population, patients on hemodialysis or peritoneal dialysis usually require four doses of 40 μg HBV vaccine.