Published online Mar 27, 2015. doi: 10.4254/wjh.v7.i3.289
Peer-review started: September 20, 2014
First decision: November 14, 2014
Revised: December 4, 2014
Accepted: December 29, 2014
Article in press: December 29, 2014
Published online: March 27, 2015
Core tip: Chronic hepatitis B (CHB) is a major global cause of liver related morbidity and mortality. Genotypes of the Hepatitis B virus have distinct geographical distributions and are known to influence a number of clinical features of disease and response to treatment. Certain well recognised viral mutations are also known to influence clinical risk of cirrhosis and hepatocellular carcinoma but in addition may have implications for vaccination programs and screening of blood for donation. This review examines the current state of knowledge about genotype and viral variants of CHB and their utility in the management of this disease.