Copyright
©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Hepatol. Dec 8, 2015; 7(28): 2811-2818
Published online Dec 8, 2015. doi: 10.4254/wjh.v7.i28.2811
Published online Dec 8, 2015. doi: 10.4254/wjh.v7.i28.2811
Bile acid receptors and nonalcoholic fatty liver disease
Liyun Yuan, Department of Gastroenterology and Liver Diseases, Keck USC School of Medicine, University of Southern California, Los Angeles, CA 90033, United States
Kiran Bambha, Division of Gastroenterology and Hepatology, University of Colorado, Aurora, CO 80045, United States
Author contributions: Yuan L performed the literature search and initial publication review, drafted the manuscript, and gave final approval of the version of the article to be submitted; Bambha K developed the concept for the manuscript, performed a literature search and publication review, critically revised the manuscript, and gave final approval of the version of the article to be submitted.
Conflict-of-interest statement: The authors have no conflicts of interest regarding this manuscript submission to report.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Kiran Bambha, MD, MSc, Assistant Professor of Medicine, Division of Gastroenterology and Hepatology, University of Colorado, Anschutz Medical Campus, 12631 E. 17th Avenue, MS B-158, Aurora, CO 80045, United States. kiran.bambha@ucdenver.edu
Telephone: +1-303-7241857 Fax: +1-303-7241891
Received: July 14, 2015
Peer-review started: July 17, 2015
First decision: September 2, 2015
Revised: November 5, 2015
Accepted: November 17, 2015
Article in press: November 25, 2015
Published online: December 8, 2015
Peer-review started: July 17, 2015
First decision: September 2, 2015
Revised: November 5, 2015
Accepted: November 17, 2015
Article in press: November 25, 2015
Published online: December 8, 2015
Core Tip
Core tip: Bile acids and bile acid receptors play important roles in modulation of feature of the metabolic syndrome, hepatic steatosis, and hepatic inflammation. Development of bile acid analogues specifically targeting farnesoid X receptor and transmembrane G protein-coupled receptor 5 provide potential novel classes of drugs for the treatment of nonalcoholic steatohepatitis.