Published online Dec 8, 2015. doi: 10.4254/wjh.v7.i28.2792
Peer-review started: April 24, 2015
First decision: July 21, 2015
Revised: September 24, 2015
Accepted: November 24, 2015
Article in press: November 25, 2015
Published online: December 8, 2015
Core tip: Hepatitis C virus (HCV) genotype (GT) 4 represents 12%-15% of total global HCV infection. It is higher in limited resource countries. Response rates to a 48-wk peg-interferon/ribavirin combination ranges from 40%-69% for HCV-GT-4. Direct-acting antivirals may significantly improve treatment outcomes in HCV- GT-4, but use of these agents in countries endemic for HCV-GT-4 is currently precluded by the very high costs. A new hepatitis C vaccine from GlaxoSmithKline has shown promise in early clinical tests, prompting strong and broad immune responses. Another Egyptian clinical trial in the field of HCV vaccination: Clinical Trials phases I and II, started on March 2011. ClinicalTrials.gov Identifier NCT01718834.