Published online Nov 18, 2015. doi: 10.4254/wjh.v7.i26.2681
Peer-review started: June 30, 2015
First decision: August 16, 2015
Revised: October 15, 2015
Accepted: November 3, 2015
Article in press: November 4, 2015
Published online: November 18, 2015
Core tip: Interferon-α (IFN-α) therapy has been playing a central role in anti-hepatitis C virus (HCV) strategies, and several viral and host factors related to the treatment efficacy have been identified. After the development of pegylated-IFN-α (Peg-IFN-α), the clinical impact of anti-IFN-α neutralizing antibodies in the treatment for HCV infection has not been sufficiently addressed. We recently found that anti-IFN-α neutralizing antibodies were associated with a non-response to Peg-IFN-α treatment. Our findings provide important information for the treatment of chronic hepatitis C in the clinical setting.