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©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Hepatol. Oct 28, 2015; 7(24): 2497-2502
Published online Oct 28, 2015. doi: 10.4254/wjh.v7.i24.2497
Published online Oct 28, 2015. doi: 10.4254/wjh.v7.i24.2497
Epigenetic mechanisms in non-alcoholic fatty liver disease: An emerging field
Rocío Gallego-Durán, Manuel Romero-Gómez, Inter-Centre Unit of Digestive Diseases and CIBERehd, Virgen Macarena - Virgen del Rocío University Hospitals, 41013 Sevilla, Spain
Rocío Gallego-Durán, Manuel Romero-Gómez, Instituto de Biomedicina de Sevilla, University of Sevilla, 41013 Sevilla, Spain
Author contributions: Gallego-Durán R and Romero-Gómez M contributed equally to this paper; both are responsible of paper design, preparation, review and final approval of the manuscript.
Supported by European Community’s Seventh Framework Programme (FP7/2007-2013) under grant agreement, No. HEALTH-F2-2009-241762 for the project FLIP; and Consejería de Salud de la Junta de Andalucía, No. PI-0488/2012.
Conflict-of-interest statement: The authors affirm there is no conflict-of-interest to declare.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Rocío Gallego-Durán, Associate Researcher, Inter-Centre Unit of Digestive Diseases and CIBERehd, Virgen Macarena - Virgen del Rocío University Hospitals, Avda. Manuel Siurot s/n, 41013 Sevilla, Spain. rociogallegoduran@gmail.com
Telephone: +34-95-5923076 Fax: +34-95-5015899
Received: January 26, 2015
Peer-review started: January 28, 2015
First decision: March 6, 2015
Revised: September 27, 2015
Accepted: October 16, 2015
Article in press: October 19, 2015
Published online: October 28, 2015
Peer-review started: January 28, 2015
First decision: March 6, 2015
Revised: September 27, 2015
Accepted: October 16, 2015
Article in press: October 19, 2015
Published online: October 28, 2015
Core Tip
Core tip: The interplay of environmental and host factors results in non-alcoholic fatty liver disease (NAFLD) development and influence its progression individually. Nevertheless, the physiopathology of this disease remains unclear, so this lack of knowledge avoids the development of new therapeutic approaches and non-invasive biomarkers. Epigenetics could be an interesting alternative to cover these issues, considering the amount of evidence accumulated in order to clarify its role on NAFLD.