Bunchorntavakul C, Maneerattanaporn M, Chavalitdhamrong D. Management of patients with hepatitis C infection and renal disease. World J Hepatol 2015; 7(2): 213-225 [PMID: 25729476 DOI: 10.4254/wjh.v7.i2.213]
Corresponding Author of This Article
Chalermrat Bunchorntavakul, MD, Assistant Professor of Medicine, Division of Gastroenterology and Hepatology, Department of Internal Medicine, Rajavithi Hospital, College of Medicine, Rangsit University, Rajavithi Road, Ratchathewi, Bangkok 10400, Thailand. dr.chalermrat@gmail.com
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Review
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Chalermrat Bunchorntavakul, Division of Gastroenterology and Hepatology, Department of Internal Medicine, Rajavithi Hospital, College of Medicine, Rangsit University, Bangkok 10400, Thailand
Monthira Maneerattanaporn, Division of Gastroenterology and Hepatology, Department of Internal Medicine, Siriraj Hospital, Faculty of Medicine, Mahidol University, Bangkok 10700, Thailand
Disaya Chavalitdhamrong, Division of Gastroenterology, Hepatology and Nutrition, Department of Internal Medicine, University of Florida, Gainesville, FL 32610, United States
Author contributions: Bunchorntavakul C conceptualized, searched and reviewed literature, created the figures, drafted and reviewed the paper; Maneerattanaporn M conceptualized the paper and drafted the HCV-related renal disease part; Chavalitdhamrong D conceptualized and critically reviewed the paper.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Chalermrat Bunchorntavakul, MD, Assistant Professor of Medicine, Division of Gastroenterology and Hepatology, Department of Internal Medicine, Rajavithi Hospital, College of Medicine, Rangsit University, Rajavithi Road, Ratchathewi, Bangkok 10400, Thailand. dr.chalermrat@gmail.com
Telephone: +66-2-3548081 Fax: +66-2-3548179
Received: August 15, 2014 Peer-review started: August 17, 2014 First decision: October 14, 2015 Revised: November 10, 2014 Accepted: November 17, 2014 Article in press: November 19, 2014 Published online: February 27, 2015
Core Tip
Core tip: Hepatitis C virus (HCV) infection in patients with end-stage renal disease (ESRD) is associated with more rapid liver disease progression and reduced graft and patients’ survival following kidney transplantation. The pharmacokinetics of interferons (IFN), ribavirin (RBV) and sofosbuvir are altered in patients with ESRD. With dose adjustment and careful monitoring, treatment of HCV can be safely utilized and successful in most patients with ESRD. direct acting antiviral (DAA)-based regimens, especially IFN-/RBV-free regimens, are preferred for patients with ESRD and kidney transplantation (KT). However, due to inadequate data on clinical safety and efficacy, DAA-based therapies are not currently recommended in patients with severe renal disease. This review will be focused on evaluations and management of HCV in ESRD, KT recipients and HCV-related renal disease, according to the available treatment options including DAA.
