Alpha-fetoprotein before and after pegylated interferon therapy for predicting hepatocellular carcinoma development
Yasuto Takeuchi, Fusao Ikeda, Hiroyuki Seki, Shintarou Nanba, Yuki Moritou, Tetsuya Yasunaka, Hideki Ohnishi, Akinobu Takaki, Kazuhiro Nouso, Kazuhide Yamamoto, Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama 700-8558, Japan
Fusao Ikeda, Hideki Ohnishi, Kazuhiro Nouso, Kazuhide Yamamoto, Department of Molecular Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama 700-0914, Japan
Toshiya Osawa, Department of Internal Medicine, Okayama Saiseikai General Hospital, Okayama 700-0013, Japan
Yasuyuki Araki, Department of Internal Medicine, Hiroshima City Hospital, Hiroshima 730-8518, Japan
Kouichi Takaguchi, Department of Internal Medicine, Kagawa Prefectural Central Hospital, Takamatsu 760-0065, Japan
Youichi Morimoto, Department of Internal Medicine, Kurashiki Central Hospital, Kurashiki 710-0052, Japan
Noriaki Hashimoto, Department of Internal Medicine, Mihara Red Cross hospital, Mihara 723-0011, Japan
Kousaku Sakaguchi, Department of Internal Medicine, Fukuyama City Hospital, Fukuyama 721-0971, Japan
Tatsuro Sakata, Department of Internal Medicine, National Hospital Organization Fukuyama Clinical Center, Fukuyama 720-0825, Japan
Masaharu Ando, Department of Internal Medicine, Mitoyo General Hospital, Kanonji 769-1601, Japan
Yasuhiro Makino, Department of Gastroenterology, National Hospital Organization Iwakuni Clinical Center, Iwakuni 740-0041, Japan
Shuji Matsumura, Department of Internal Medicine, Sumitomo Besshi Hospital, Niihama 792-8543, Japan
Hiroki Takayama, Department of Gastroenterology, Tsuyama Central Hospital, Okayama 708-0841, Japan
Yoshiaki Iwasaki, Health Service Center, Okayama University, Okayama 700-0914, Japan
Author contributions: All authors contributed to this manuscript.
Supported by In part a Research Program for Intractable Disease by the Ministry of Health, Labor, and Welfare of Japan (to Iwasaki Y).
Institutional review board statement: All protocols were approved by the ethics committees of the institutes.
Informed consent statement: Written informed consent was obtained from all patients.
Conflict-of-interest statement: No conflict-of-interest exists for the article.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Fusao Ikeda, MD, Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Okayama 700-8558, Japan. firstname.lastname@example.org
Telephone: +81-86-2357219 Fax: +81-86-2255991
Received: March 18, 2015
Peer-review started: March 22, 2015
First decision: April 27, 2015
Revised: June 20, 2015
Accepted: June 30, 2015
Article in press: July 2, 2015
Published online: September 8, 2015