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©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Hepatol. Jul 8, 2015; 7(13): 1725-1729
Published online Jul 8, 2015. doi: 10.4254/wjh.v7.i13.1725
Published online Jul 8, 2015. doi: 10.4254/wjh.v7.i13.1725
Is there a role for adaptive immunity in nonalcoholic steatohepatitis?
Salvatore Sutti, Aastha Jindal, Stefania Bruzzì, Irene Locatelli, Cristina Bozzola, Emanuele Albano, Department of Health Sciences and Interdisciplinary Research Centre for Autoimmune Diseases, University “Amedeo Avogadro” of East Piedmont, 28100 Novara, Italy
Author contributions: Sutti S and Jindal A equally contributed to the work; all authors contributed to this manuscript.
Conflict-of-interest statement: Nothing to disclose.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Dr. Salvatore Sutti, Department of Health Science and Interdisciplinary Research Centre for Autoimmune Diseases, University “Amedeo Avogadro” of East Piedmont, Via Solaroli 17, 28100 Novara, Italy. salvatore.sutti@med.unipmn.it
Telephone: +39-0321-660650 Fax: +39-0321-620421
Received: January 13, 2015
Peer-review started: January 16, 2015
First decision: March 6, 2015
Revised: April 13, 2015
Accepted: April 28, 2015
Article in press: April 30, 2015
Published online: July 8, 2015
Peer-review started: January 16, 2015
First decision: March 6, 2015
Revised: April 13, 2015
Accepted: April 28, 2015
Article in press: April 30, 2015
Published online: July 8, 2015
Core Tip
Core tip: Nonalcoholic fatty liver disease (NAFLD) is becoming one of the most common hepatic diseases, yet the factors responsible for the wide inter-individual variability in NAFLD evolution to nonalcoholic steatohepatitis are still poorly understood. In this Editorial, we comment on recent evidence suggesting the involvement of adaptive immune responses in sustaining hepatic inflammation during NAFLD evolution.