Review
Copyright ©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Hepatol. Jun 18, 2015; 7(11): 1530-1540
Published online Jun 18, 2015. doi: 10.4254/wjh.v7.i11.1530
MicroRNAs dysregulation in hepatocellular carcinoma: Insights in genomic medicine
Iván Lyra-González, Laura E Flores-Fong, Ignacio González-García, David Medina-Preciado, Juan Armendáriz-Borunda
Iván Lyra-González, Laura E Flores-Fong, Ignacio González-García, David Medina-Preciado, Juan Armendáriz-Borunda, Departamento de Biología Molecular y Genómica, CUCS, Universidad de Guadalajara, Instituto de Biología Molecular en Medicina y Terapia Génica, Guadalajara, Jalisco 44281, México
Ignacio González-García, O.P.D. Hospital Civil de Guadalajara “Fray Antonio Alcalde”, Guadalajara, Jalisco 44281, México
David Medina-Preciado, O.P.D. Hospital Civil de Guadalajara “Juan I. Menchaca”, Guadalajara, Jalisco 44281, México
Juan Armendáriz-Borunda, Departamento de Biología Molecular y Genómica, CUCS, Universidad de Guadalajara, Guadalajara, Jalisco 44281, México
Author contributions: All the authors equally contributed to this work.
Conflict-of-interest: Authors have no conflict of interests related to this manuscript. All authors have contributed equally in the realization of this manuscript.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Dr. Juan Armendariz-Borunda, PhD, Head, Departamento de Biología Molecular y Genómica, CUCS, Universidad de Guadalajara, Sierra Mojada # 950, Guadalajara, Jalisco 44281, Mexico. armdbo@gmail.com
Telephone: +52-33-10585317 Fax: +52-33-10585318
Received: September 17, 2014
Peer-review started: September 20, 2014
First decision: November 27, 2014
Revised: December 22, 2014
Accepted: May 8, 2015
Article in press: May 11, 2015
Published online: June 18, 2015
Core Tip

Core tip: MicroRNAs are implicated in the control of gene expression which enable them a relevant new target for diagnosis, prognosis and treatment in a wide variety of pathologic entities, including hepatocellular carcinoma (HCC). This manuscript represents an attempt to summarize current knowledge regarding miRNAs and their role in HCC development.