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Perini MV, Starkey G, Fink MA, Bhandari R, Muralidharan V, Jones R, Christophi C. From minimal to maximal surgery in the treatment of hepatocarcinoma: A review. World J Hepatol 2015; 7(1): 93-100 [PMID: 25625000 DOI: 10.4254/wjh.v7.i1.93]
World J Hepatol. Jan 27, 2015; 7(1): 93-100 Published online Jan 27, 2015. doi: 10.4254/wjh.v7.i1.93
From minimal to maximal surgery in the treatment of hepatocarcinoma: A review
Marcos Vinicius Perini, Graham Starkey, Michael A Fink, Ramesh Bhandari, Vijayaragavan Muralidharan, Robert Jones, Christopher Christophi
Marcos Vinicius Perini, Graham Starkey, Michael A Fink, Ramesh Bhandari, Vijayaragavan Muralidharan, Robert Jones, Christopher Christophi, Austin Health, Department of Surgery, University of Melbourne, Heidelberg, VIC 3084, Australia
Author contributions: Perini MV designed the review, collected data, wrote the manuscript; Starkey G reviewed the manuscript; Fink MA, Bhandari R, Muralidharan V, Jones R and Christophi C reviewed the manuscript.
Correspondence to: Marcos Vinicius Perini, MD, PhD, Austin Health, Department of Surgery, University of Melbourne, 145 Studley Road, Level 8, Heidelberg, VIC 3084, Australia. marcos.perini@unimelb.edu.au
Telephone: +61-422-493101 Fax: +61-394-963670
Received: September 11, 2014 Peer-review started: September 13, 2014 First decision: October 14, 2014 Revised: October 28, 2014 Accepted: November 17, 2014 Article in press: November 19, 2014 Published online: January 27, 2015 Processing time: 121 Days and 0.7 Hours
Core Tip
Core tip: The decision making approach to the cirrhotic patient with hepatocellular carcinoma (HCC) represents one of the most challenging frontiers in liver surgery and, as a result, should involve a multidisciplinary assessment. Despite the advances in non-surgical therapies, surgery is still the treatment that can offer the best survival. In patients submitted to liver resection who experience recurrence, re-resection or salvage liver transplantation has been shown to be an alternative approach in well-selected cases. We herein discuss some controversial topics regarding the surgical treatment of HCC: anatomical resection, margin status, macro-vascular invasion, laparoscopic resection, salvage liver transplantation and liver transplantation.
