Copyright
©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
Immune mechanisms of vaccine induced protection against chronic hepatitis C virus infection in chimpanzees
Babs E Verstrepen, Gerrit Koopman, Department of Virology, Biomedical Primate Research Centre, 2280GH Rijswijk, The Netherlands
André Boonstra, Department of Gastroenterology and Hepatology, Erasmus University Medical Center Rotterdam, 3015 CE Rotterdam, The Netherlands
Author contributions: Verstrepen BE, Boonstra A and Koopman G wrote the paper.
Supported by In part the Fifth framework program from the EU, No. BIO-CT98-0357, QLK2-CT-1999-00356 and ERC-2008-AdG-233130-HEPCENT (Verstrepen BE); by the Virgo consortium, funded by the Dutch government project, No. FES0908 (Boonstra A)
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Gerrit Koopman, PhD, Department of Virology, Biomedical Primate Research Centre, PO Box 3306, 2280GH Rijswijk, The Netherlands. koopman@bprc.nl
Telephone: +31-15-2842761
Received: August 27, 2014
Peer-review started: August 31, 2014
First decision: September 28, 2014
Revised: October 22, 2014
Accepted: November 7, 2014
Article in press: November 10, 2014
Published online: January 27, 2015
Peer-review started: August 31, 2014
First decision: September 28, 2014
Revised: October 22, 2014
Accepted: November 7, 2014
Article in press: November 10, 2014
Published online: January 27, 2015
Core Tip
Core tip: With the near disappearance of the most relevant animal model for hepatitis C virus (HCV), the chimpanzee, we review the progression that has been made regarding vaccine development against this virus infection. An estimated 3 million people suffering from chronic hepatitis caused by HCV die each year. Currently, there is no approved vaccine available to prevent new infection.