Published online Aug 27, 2014. doi: 10.4254/wjh.v6.i8.538
Revised: May 7, 2014
Accepted: June 10, 2014
Published online: August 27, 2014
Core tip: Hepatitis C virus (HCV) infection during pregnancy is an emerging problem. While not negatively affecting acute hepatitis, it may exacerbate chronic hepatitis and worsen liver function in woman with liver cirrhosis. HCV does not affect delivery outcome apart from an increased risk of premature membrane rupture and cesarean delivery. The mother-to-child HCV transmission rate is low (3%-5%) and is related to high maternal viremia, human immunodeficiency virus (HIV) coinfection, prolonged rupture of membranes, vaginal lacerations and invasive fetal monitoring. Cesarean delivery and no breastfeeding are indicated for HIV/HCV coinfected women. Antiviral therapy is not routinely offered to pregnant women and infants because of its side effects.