Samonakis DN, Koulentaki M, Coucoutsi C, Augoustaki A, Baritaki C, Digenakis E, Papiamonis N, Fragaki M, Matrella E, Tzardi M, Kouroumalis EA. Clinical outcomes of compensated and decompensated cirrhosis: A long term study. World J Hepatol 2014; 6(7): 504-512 [PMID: 25068002 DOI: 10.4254/wjh.v6.i7.504]
Corresponding Author of This Article
Dr. Dimitrios N Samonakis, Department of Gastroenterology and Hepatology, University Hospital of Heraklion, Buidling A-4th Floor, Voutes, Herklion 71110, Crete, Greece. dsamonakis@gmail.com
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Retrospective Study
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World J Hepatol. Jul 27, 2014; 6(7): 504-512 Published online Jul 27, 2014. doi: 10.4254/wjh.v6.i7.504
Clinical outcomes of compensated and decompensated cirrhosis: A long term study
Dimitrios N Samonakis, Mairi Koulentaki, Constantina Coucoutsi, Aikaterini Augoustaki, Chryssavgi Baritaki, Emmanuel Digenakis, Nikolaos Papiamonis, Maria Fragaki, Erminia Matrella, Maria Tzardi, Elias A Kouroumalis
Dimitrios N Samonakis, Mairi Koulentaki, Constantina Coucoutsi, Aikaterini Augoustaki, Chryssavgi Baritaki, Emmanuel Digenakis, Nikolaos Papiamonis, Maria Fragaki, Erminia Matrella, Elias A Kouroumalis, Department of Gastroenterology and Hepatology, University Hospital of Heraklion, Heraklion 71110, Crete, Greece
Maria Tzardi, Department of Histopathology, University Hospital of Heraklion, Heraklion 71110, Crete, Greece
Author contributions: Samonakis DN wrote the manuscript, did the statistics and was responsible for patient management; Koulentaki M contributed to data base design, patient management and paper corrections; Coucoutsi C, Augustaki A and Baritaki C kept data base and patient management; Digenakis E, Papiamonis N and Fragaki M contributed to patient management and data base update, patient survival follow up; Matrella E contributed to long term patient management and outpatient clinic details; Tzardi M diagnosed all liver biopsies; Kouroumalis EA contributed to the study design, patient managment, contributed to the manuscript, had overall responsibility for the study.
Correspondence to: Dr. Dimitrios N Samonakis, Department of Gastroenterology and Hepatology, University Hospital of Heraklion, Buidling A-4th Floor, Voutes, Herklion 71110, Crete, Greece. dsamonakis@gmail.com
Telephone: +30-2810-392356 Fax: +30-2810-542085
Received: December 27, 2013 Revised: May 16, 2014 Accepted: June 10, 2014 Published online: July 27, 2014
Core Tip
Core tip: Hepatitis C was the most common cause in our cirrhotics and many hepatitis C virus patients were aged and demonstrated a long, mild course. Alcoholic and non alcoholic steatohepatitis cirrhosis is becoming a significant problem. Ascites was the commonest type of decompensation. Survival in compensated cirrhotics was at least double that of decompensated patients. Variceal bleeding was more frequent in alcoholics; nevertheless it was unexpectedly related to better survival than decompensation with ascites or encephalopathy. This was attributed to the improvements in the management of variceal bleeding together with the importance of abstinence from alcohol after the episode was successfully treated. Hepatocellular carcinoma patients with a history of hepatitis B virus had the highest risk of mortality.
