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World J Hepatol. May 27, 2014; 6(5): 340-346
Published online May 27, 2014. doi: 10.4254/wjh.v6.i5.340
Published online May 27, 2014. doi: 10.4254/wjh.v6.i5.340
CYP2E1 immunoglobulin G4 subclass antibodies after desflurane anesthesia
Chrysanthi Batistaki, George Michalopoulos, Paraskevi Matsota, Konstantinos Kalimeris, Maria Riga, Maria Nakou, Georgia Kostopanagiotou, 2nd Department of Anesthesiology, School of Medicine, University of Athens, “Attikon” University Hospital, 12462 Athens, Greece
George Michalopoulos, Department of Gastroenterology, “Tzaneion” Peripheral General Hospital, 18536 Piraeus, Greece
Tzortzis Nomikos, Department of Nutrition and Dietetics, Harokopio University, 17671 Athens, Greece
Author contributions: All authors made substantial contributions to the conception and design, acquisition of data or analysis and interpretation of the data; drafted the article or revised it, critically, for important intellectual content; and provided final approval for the version to be published; Batistaki C and Michalopoulos G contributed equally to this work, with regards to the conception and design, the conduct of the study, acquisition of data, analysis and interpretation of data, and manuscript preparation; Matsota P and Kalimeris K contributed to study design and manuscript preparation; Riga M and Nakou M contributed to conducting the study; Nomikos T contributed to biochemical analysis of data; and Kostopanagiotou G contributed to study design and manuscript preparation.
Correspondence to: Chrysanthi Batistaki, Assistant Professor of Anesthesiology, 2nd Department of Anesthesiology, School of Medicine, University of Athens, “Attikon” University Hospital, 1 Rimini str, 12462 Athens, Greece. chrysabatistaki@yahoo.gr
Telephone: +30-694-1466185 Fax: +30-210-5326413
Received: November 2, 2013
Revised: January 20, 2014
Accepted: March 3, 2014
Published online: May 27, 2014
Revised: January 20, 2014
Accepted: March 3, 2014
Published online: May 27, 2014
Core Tip
Core tip: Several case reports of hepatotoxicity following anesthesia with desflurane have been published in the literature, implicating cytochrome P450 2E1-IgG4 autoantibodies. This study investigates the possible changes in CYP2E1 IgG4 autoantibody levels and other biochemical markers of liver injury in 40 adult patients who received anesthesia with desflurane for elective surgery. Samples were obtained before and 96 h after exposure to desflurane, and no significant difference was observed in levels of CYP2E1 IgG4, a-glutamyl-S-transferase, aspartate aminotransferase, alanine aminotransferase, g-glutamyl-transpeptidase or alkaline phosphatase levels, regardless of patients’ previous exposure to volatile anesthetics.