Original Article
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World J Hepatol. Apr 27, 2014; 6(4): 230-242
Published online Apr 27, 2014. doi: 10.4254/wjh.v6.i4.230
Melatonin attenuates cisplatin-induced HepG2 cell death via the regulation of mTOR and ERCC1 expressions
Kangsadarn Bennukul, Sucha Numkliang, Vijittra Leardkamolkarn
Kangsadarn Bennukul, Sucha Numkliang, Toxicology Graduate Programme, Faculty of Science, Mahidol University, Bangkok 10400, Thailand
Vijittra Leardkamolkarn, Department of Anatomy, Faculty of Science, Mahidol University, Bangkok 10400, Thailand
Vijittra Leardkamolkarn, Center of Excellence on Environmental Health and Toxicology, Mahidol University, Bangkok 10400, Thailand
Author contributions: Bennukul K and Leardkamolkarn V contributed to experimental design, coordinate the study, interpret the data, writing and revising the manuscript; Numkliang S performed an immunocytochemistry experiment.
Supported by Center of Excellence on Environmental Health and Toxicology, Science and Technology Postgraduate Education and Research Development Office, Thailand Ministry of Education
Correspondence to: Vijittra Leardkamolkarn, PhD, Associate Professor, Department of Anatomy, Faculty of Science, Mahidol University, Rama VI Road, Bangkok 10400, Thailand. vijittra.lea@mahidol.ac.th
Telephone: +66-2-2015402 Fax: +66-2-3547168
Received: October 25, 2013
Revised: January 9, 2014
Accepted: April 3, 2014
Published online: April 27, 2014
Core Tip

Core tip: Melatonin has anti-oxidative stress and anti-proliferative effects on cisplatin-treated hepatocellular carcinoma cells through a counter-balance between the roles of apoptosis and autophagy proteins. Melatonin also reduced cisplatin-induced DNA damage by decreasing the activation of excision repair cross complementary 1 in the DNA repair system. Thus, co-treatment with melatonin to ameliorate cisplatin adverse effects might be beneficial for Hepatocellular carcinoma therapy.