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World J Hepatol. Feb 27, 2014; 6(2): 98-106
Published online Feb 27, 2014. doi: 10.4254/wjh.v6.i2.98
Published online Feb 27, 2014. doi: 10.4254/wjh.v6.i2.98
Methylsulfonylmethane suppresses hepatic tumor development through activation of apoptosis
Joo-Hyun Kim, Hye-Jun Shin, Hye-Lin Ha, Young-Ho Park, Tae-Ho Kwon, Mi-Ra Jung, Dae-Yeul Yu, Aging Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon 305-806, South Korea
Hyung-Bae Moon, Wonkwang University College of Medicine, Iksan 570-749, South Korea
Joo-Hyun Kim, Eun-Sang Cho, Hwa-Young Son, College of Veterinary Medicine, Chungnam National University, Daejeon 305-764, South Korea
Author contributions: Kim JH, Ha HL, Son HY and Yu DY planned the experiments and analyses; Kim JH, Ha HL, Shin HJ, Park YH, Kwon TH, Jung MR, Moon HB, Cho ES, Son HY and Yu DY performed the experiments and analyzed the results; Kim JH and Yu DY wrote the manuscript; all the authors discussed the results and commented on the manuscript.
Supported by The World Class Institute (WCI) Program of the National Research Foundation of Korea (NRF), No. WCM0101222; Ministry of Education, Science and Technology of Korea (MEST), the National R and D Program for Cancer Control, Ministry of Health and Welfare, South Korea, No. BCM0061213; KRIBB Research Initiative Program Grant, No. KGM3141312
Correspondence to: Dae-Yeul Yu, PhD, Aging Research Center, Korea Research Institute of Bioscience and Biotechnology, 125 Gwahak-ro, Yuseong-gu, Daejeon 305-806, South Korea. dyyu10@kribb.re.kr
Telephone: +82-42-8604422 Fax: +82-42-8604609
Received: August 29, 2013
Revised: December 2, 2013
Accepted: December 12, 2013
Published online: February 27, 2014
Revised: December 2, 2013
Accepted: December 12, 2013
Published online: February 27, 2014
Core Tip
Core tip: Methylsulfonylmethane (MSM) is an organic sulfur-containing compound. MSM suppressed hepatic tumor growth through activation of apoptosis. MSM could be a potential candidate as an anti-liver cancer agent.