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World J Hepatol. Dec 27, 2014; 6(12): 894-900
Published online Dec 27, 2014. doi: 10.4254/wjh.v6.i12.894
Transitions of histopathologic criteria for diagnosis of nonalcoholic fatty liver disease during the last three decades
Yoshihiro Ikura
Yoshihiro Ikura, Department of Pathology, Takatsuki General Hospital, Kosobecho, Takatsuki 569-1192, Japan
Author contributions: Ikura Y solely contributed to this paper.
Supported by Grant-in-Aid for Scientific Research, No. 24890207
Correspondence to: Yoshihiro Ikura, MD, Department of Pathology, Takatsuki General Hospital, 1-3-13, Kosobecho, Takatsuki 569-1192, Japan.
Telephone: +81-72-6813801 Fax: +81-72-6823834
Received: August 29, 2014
Revised: October 9, 2014
Accepted: October 28, 2014
Published online: December 27, 2014
Core Tip

Core tip: The differentiation between nonalcoholic steatohepatitis and simple steatosis can be done only by liver biopsy. Through many proposals and revisions, the histological criteria for the differentiation have been changed. The changes in the criteria during the last three decades are exhibited in this review article, with a special interest in “hepatocellular ballooning”.