Published online Oct 27, 2014. doi: 10.4254/wjh.v6.i10.759
Revised: July 29, 2014
Accepted: September 6, 2014
Published online: October 27, 2014
Core tip: Hepatitis C is a world health problem and represents a dynamic field of research for new therapeutic options. Recently direct antiviral agents such as protease inhibitors have been developed which, in addition to pegylated interferon-α and Ribavirin, obtain higher sustained virological response (SVR) rates. Of note, costs are higher and side effects are more common. The data regarding the predictive value of Interleukin 28B (IL-28B) are controversial. This meta-analysis was conducted on 2707 patients treated with different protease inhibitors. Its aim was to clarify the predictive value of IL-28B on SVR in protease inhibitor-based triple-therapy, allowing the possibility of personalized treatment.