Effects of fullerenol C60 on hepatic ischemia-reperfusion injury in desflurane-anesthetized rats

doi:10.4254/wjh.122845

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World Journal of Hepatology

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1948-5182

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Basic Study

Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Hepatol. Sep 27, 2026; 18(9): 122845
Published online Sep 27, 2026. doi: 10.4254/wjh.122845

Effects of fullerenol C60 on hepatic ischemia-reperfusion injury in desflurane-anesthetized rats

Esat Kasapbasi, Cagri Ozdemir, Aydin Yavuz, Saban Cem Sezen, Omer Kurtipek, Mustafa Kavutçu, Mustafa Arslan

Esat Kasapbasi, Department of Anesthesiology and Reanimation, 29 Mayıs State Hospital, Ankara 06000, Türkiye

Cagri Ozdemir, Omer Kurtipek, Mustafa Arslan, Department of Anesthesiology and Reanimation, Gazi University Faculty of Medicine, Ankara 06000, Türkiye

Aydin Yavuz, Department of General Surgery, Gazi University Faculty of Medicine, Ankara 06000, Türkiye

Saban Cem Sezen, Department of Histology and Embryology, Kırıkkale University Faculty of Medicine, Kırıkkale 71450, Türkiye

Mustafa Kavutçu, Department of Medical Biochemistry, Gazi University Faculty of Medicine, Ankara 06000, Türkiye

Mustafa Arslan, Life Sciences Application and Research Center, Gazi University Faculty of Medicine, Ankara 06000, Türkiye

Mustafa Arslan, Laboratory Animal Breeding and Experimental Researches Center (GÜDAM), Gazi University Faculty of Medicine, Ankara 06000, Türkiye

Author contributions: Arslan M was responsible for conceptualization, study protocol development, supervision of experimental procedures and overall project coordination; Kurtipek O was responsible for preparation for statistical analysis, data interpretation manuscript writing; Kasapbasi E was responsible for project coordination and manuscript writing, experimental procedures; Kavutçu M was responsible for biochemical analyses and interpretation of biochemical findings; Ozdemir C was responsible for experimental procedures, data collection and data organization; Sezen SC was responsible for histopathological examinations and interpretation of histological findings; Yavuz A was responsible for study protocol, development and supervision of experimental procedures.

AI contribution statement: No artificial intelligence tools were used in the preparation, writing, analysis, or editing of this manuscript.

Institutional animal care and use committee statement: The experimental protocol was reviewed and approved by the Gazi University Experimental Animals Ethics Committee prior to the study (Approval No. G.Ü.ET-22.021; Approval date: February 24, 2022).

Conflict-of-interest statement: The authors declare that they have no conflicts of interest regarding the publication of this paper.

ARRIVE guidelines statement: The authors have read the ARRIVE guidelines, and the manuscript was prepared and revised according to the ARRIVE guidelines.

Data sharing statement: The data supporting the findings of this study are available from the corresponding author upon reasonable request.

Corresponding author: Cagri Ozdemir, Doctor, Assistant Professor, Department of Anesthesiology and Reanimation, Gazi University Faculty of Medicine, Kazakistan Caddesi 1d, Ankara 06000, Türkiye. cagriozdemir@gazi.edu.tr

Received: April 29, 2026
Revised: July 3, 2026
Accepted: August 28, 2026
Published online: September 27, 2026
Processing time: 141 Days and 8.8 Hours

Core Tip

Core Tip: Hepatic ischemia-reperfusion injury (IRI) remains a major challenge during liver surgery and transplantation because oxidative stress and inflammation can cause significant tissue damage. This experimental study demonstrated that fullerenol C60 significantly reduced lipid peroxidation, preserved endogenous antioxidant enzyme activity, and improved histopathological liver injury in desflurane-anesthetized rats. Desflurane also provided partial protection, although the combined treatment showed no clear superiority over fullerenol alone. These findings suggest that fullerenol C60 may be a promising adjunctive strategy for limiting hepatic IRI and preserving liver function. Further translational and clinical studies are required to confirm optimal dosing, mechanisms, safety, and therapeutic applicability in humans.