Review
Copyright ©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Hepatol. Aug 27, 2025; 17(8): 108182
Published online Aug 27, 2025. doi: 10.4254/wjh.v17.i8.108182
Nutrients as epigenetic modulators in metabolic dysfunction-associated steatotic liver disease
Santiago Rodriguez, Maria Luiza Fernandes Dahlem, Carina Rossoni, Norma P Marroni, Claudio A Marroni, Sabrina Alves Fernandes
Santiago Rodriguez, Directorate of Postgraduate Studies in Health Sciences, Universidad de las Américas, Quito 170521, Ecuador
Santiago Rodriguez, Department of Hepatology, Hospital Vozandes Quito-HVQ, Quito 170521, Ecuador
Maria Luiza Fernandes Dahlem, Department of Biochemistry, Universidade Federal do Rio Grande do Sul, Porto Alegre 91540-000, Brazil
Carina Rossoni, Faculty of Medicine, Institute of Environmental Health, University of Lisbon, Lisboa 1649-026, Portugal
Norma P Marroni, Department of Biologycal Sciences-Physiology, Universidade Federal do Rio Grande do Sul, Porto Alegre 91540-000, Rio Grande do Sul, Brazil
Norma P Marroni, Department of Medical Sciences, Universidade Federal do Rio Grande do Sul, Porto Alegre 90035-003, Brazil
Claudio A Marroni, Department of Hepatology, Universidade Federal de Ciências da Saúde de Porto Alegre, Porto Alegre 90050-170, Brazil
Sabrina Alves Fernandes, Santa Casa de Porto Alegre Hospital Complex, Porto Alegre 90020-090, Rio Grande do Sul, Brazil
Co-first authors: Santiago Rodriguez and Maria Luiza Fernandes Dahlem.
Author contributions: Rodriguez S and Dahlem MLF contributed equally to this study as co-first authors; all authors contributed to the literature review and writing of the article; Fernandes SA conceived the research project and critically revised the manuscript; all authors read and approved the final manuscript.
Conflict-of-interest statement: The authors of this article have no conflict of interest.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Sabrina Alves Fernandes, PhD, Researcher, Santa Casa de Porto Alegre Hospital Complex, Professor Duplan Street, 72, apt 01, Porto Alegre 90020-090, Rio Grande do Sul, Brazil. sabrinaafernandes@gmail.com
Received: April 7, 2025
Revised: May 24, 2025
Accepted: July 23, 2025
Published online: August 27, 2025
Processing time: 142 Days and 10.3 Hours
Core Tip

Core Tip: Metabolic dysfunction-associated steatotic liver disease is a complex disease with multifactorial causes. The individual's dietary pattern contributes significantly to the progression of this disease. Epigenetics, modulated by diet, is a key process helps explain the development as well as new therapeutic targets for the disease.