Observational Study
Copyright ©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Hepatol. Jun 27, 2025; 17(6): 107931
Published online Jun 27, 2025. doi: 10.4254/wjh.v17.i6.107931
Dietary ω-3 polyunsaturated fatty acid intake improves skeletal muscle mass in patients with metabolic dysfunction-associated fatty liver disease: A nationwide cross-sectional study
Li-Zhan Bie, Chao Wu, Jia-Lu Wang
Li-Zhan Bie, Department of Cardiology, Affiliated Hospital 6 of Nantong University, Yancheng Third People’s Hospital, Yancheng 224000, Jiangsu Province, China
Chao Wu, Department of General Surgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200020, China
Jia-Lu Wang, Department of Geriatrics, Zhongshan Hospital, Fudan University, Shanghai 200032, China
Co-first authors: Li-Zhan Bie and Chao Wu.
Author contributions: Wang JL and Bie LZ designed the study, analysis and interpretation, and were primarily responsible for drafting and revising the manuscript; Wang JL, Wu C and Bie LZ were responsible for statistical analysis and methodology; Bie LZ and Wu C were deeply involved in data analysis and interpretation; Wang JL providing significant review and editing contributions. All authors were involved in data interpretation, reviewed the manuscript, and approved the final version.
Supported by The National Natural Science Foundation of China, No. 82103356.
Institutional review board statement: This study was approved by the National Center for Health Statistic Ethics Review Board.
Informed consent statement: This study was approved by the National Center for Health Statistic Ethics Review Board.
Conflict-of-interest statement: The authors declare no conflict of interest.
STROBE statement: The authors have read the STROBE Statement-checklist of items, and the manuscript was prepared and revised according to the STROBE Statement- checklist of items.
Data sharing statement: Publicly available datasets were analyzed in this study. This data can be found here: https://wwwn.cdc.gov/nchs/nhanes/ContinuousNhanes/Default.aspx?BeginYear= %202005.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Jia-Lu Wang, MD, PhD, Department of Geriatrics, Zhongshan Hospital, Fudan University, No. 180 Fenglin Road, Xuhui District, Shanghai 200032, China. wang.jialu@zs-hospital.sh.cn
Received: March 31, 2025
Revised: April 22, 2025
Accepted: June 4, 2025
Published online: June 27, 2025
Processing time: 86 Days and 1.3 Hours
Core Tip

Core Tip: This study found that dietary intake of ω-3 polyunsaturated fatty acids improved skeletal muscle mass in patients with metabolic dysfunction-associated fatty liver disease, and patients with obesity and higher metabolic risk were more likely to benefit from supplementation with docosahexaenoic acid. These results fill a gap in muscle nutrient metabolism in patients with fatty liver disease.