Role of zinc finger protein 71 in hepatocellular carcinoma: Methodological concerns, clinical relevance, and future directions

doi:10.4254/wjh.v17.i6.106573

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Jun 27, 2025 (publication date) through Jun 25, 2025

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World Journal of Hepatology

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1948-5182

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Letter to the Editor

World J Hepatol. Jun 27, 2025; 17(6): 106573
Published online Jun 27, 2025. doi: 10.4254/wjh.v17.i6.106573

Role of zinc finger protein 71 in hepatocellular carcinoma: Methodological concerns, clinical relevance, and future directions

Arunkumar Krishnan, Diptasree Mukherjee

Arunkumar Krishnan, Department of Supportive Oncology, Atrium Health Levine Cancer, Charlotte, NC 28204, United States

Diptasree Mukherjee, Department of Medicine, Apex Institute of Medical Science, Kolkata 700075, West Bengal, India

Author contributions: Krishnan A contributed to the concept of the study, drafted the manuscript, and participated in the review and editing; Krishnan A and Mukherjee D were involved with critically revising the manuscript for important intellectual content, they contributed equally to this article; and all authors reviewed and approved the final version of the manuscript.

Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.

Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/

Corresponding author: Arunkumar Krishnan, MD, Department of Supportive Oncology, Atrium Health Levine Cancer, 1021 Morehead Medical Drive, Suite 70100, Charlotte, NC 28204, United States. dr.arunkumar.krishnan@gmail.com

Received: March 3, 2025
Revised: April 15, 2025
Accepted: May 13, 2025
Published online: June 27, 2025
Processing time: 116 Days and 18.8 Hours

Core Tip

Core Tip: A study by Qin et al showed significant upregulation of zinc finger protein 71 (ZNF71) in hepatocellular carcinoma and its association with disease progression. While their findings are valuable, limitations include the need for diverse patient cohorts, larger non-cancerous tissue samples, and functional validation through in vitro and in vivo studies. Statistical improvements, multivariate regression, and multiple comparison corrections are essential. Future research should integrate genomic, epigenomic, and tumor microenvironment data to compare ZNF71 with established biomarkers, such as alpha-fetoprotein. Addressing these gaps will strengthen ZNF71’s potential as a diagnostic and therapeutic target in hepatocellular carcinoma.