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World J Hepatol. May 27, 2025; 17(5): 104724
Published online May 27, 2025. doi: 10.4254/wjh.v17.i5.104724
Understanding acute kidney injury in cirrhosis: Current perspective
Sayan Malakar, Sumit Rungta, Arghya Samanta, Umair Shamsul Hoda, Piyush Mishra, Gaurav Pande, Akash Roy, Suprabhat Giri, Praveer Rai, Samir Mohindra, Uday C Ghoshal
Sayan Malakar, Department of Gastroenterology, King George's Medical University, Lucknow 226003, Uttar Pradesh, India
Sumit Rungta, Department of Medical Gastroenterology, King George's Medical University, Lucknow 226003, Uttar Pradesh, India
Arghya Samanta, Department of Pediatric Gastroenterology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow 226014, Uttar Pradesh, India
Umair Shamsul Hoda, Piyush Mishra, Gaurav Pande, Praveer Rai, Samir Mohindra, Uday C Ghoshal, Department of Gastroenterology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow 226014, Uttar Pradesh, India
Akash Roy, Department of Gastrosciences and Liver Transplantation, Apollo Multispeciality Hospitals, Kolkata 700054, West Bengal, India
Suprabhat Giri, Department of Gastroenterology and Hepatology, Kalinga Institute of Medical Sciences, Bhubaneswar 751024, Odisha, India
Author contributions: Malakar S, Mishra P, Hoda US, Pande G, and Rungta S contributed to the preparation of the manuscript; Roy A, Samanta A, Ghoshal UC, Mohindra S, Rai P, and Giri S contributed to the supervision of the project, revision of the manuscript, and intellectual input; Malakar S, Hoda US, and Mishra P contributed to preparation of the final draft.
Conflict-of-interest statement: The authors have no conflicts of interest to declare.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Sumit Rungta, Department of Medical Gastroenterology, King George's Medical University, Chowk, Lucknow 226003, Uttar Pradesh, India. drsumitrungta79@gmail.com
Received: December 31, 2024
Revised: March 13, 2025
Accepted: April 15, 2025
Published online: May 27, 2025
Processing time: 148 Days and 15 Hours
Core Tip

Core Tip: The development of acute kidney injury (AKI) changes the trajectory of the natural history of patients with decompensated cirrhosis or acute-on-chronic-liver failure. With the discovery of newer biomarkers and a better understanding of hemodynamics in patients with AKI and cirrhosis, there is a paradigm shift in the management of such patients. This comprehensive review focuses on the current perspective of the pathophysiology, diagnosis, and management of patients with AKI in cirrhosis.