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Krishnan A, Mukherjee D. Association of cardiovascular health metrics and metabolic associated fatty liver disease: Methodological limitations, and future directions. World J Hepatol 2025; 17(3): 105635 [PMID: 40177198 DOI: 10.4254/wjh.v17.i3.105635]
World J Hepatol. Mar 27, 2025; 17(3): 105635 Published online Mar 27, 2025. doi: 10.4254/wjh.v17.i3.105635
Association of cardiovascular health metrics and metabolic associated fatty liver disease: Methodological limitations, and future directions
Arunkumar Krishnan, Diptasree Mukherjee
Arunkumar Krishnan, Department of Supportive Oncology, Atrium Health Levine Cancer, Charlotte, NC 28204, United States
Diptasree Mukherjee, Department of Medicine, Apex Institute of Medical Science, Kolkata 700075, West Bengal, India
Author contributions: Krishnan A contributed to the concept of the study; Krishnan A and Mukherjee D were involved with critically revising the manuscript for important intellectual content, drafted the manuscript and participated in the review and editing; and all authors reviewed and approved the final version of the manuscript.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Corresponding author: Arunkumar Krishnan, MD, Associate Professor, Senior Researcher, Department of Supportive Oncology, Atrium Health Levine Cancer, 1021 Morehead Medical Drive, Suite 70100, Charlotte, NC 28204, United States. dr.arunkumar.krishnan@gmail.com
Received: February 2, 2025 Revised: February 21, 2025 Accepted: February 27, 2025 Published online: March 27, 2025 Processing time: 54 Days and 3.5 Hours
Core Tip
Core Tip: A study by Fu et al investigated the association between cardiovascular health metrics, specifically Life’s Simple 7 and the updated Life’s Essential 8, and the prevalence of metabolic-associated fatty liver disease (MAFLD) and used Life’s Simple as an effective tool for assessing the risk of MAFLD. However, the methodological limitations, such as cross-sectional design and unaddressed confounding factors, hinder the ability to draw causal conclusions. Future research should focus on longitudinal studies, advanced statistical approaches, and comprehensive adjustments for confounders. A better understanding of the relationship between cardiovascular health and MAFLD could lead to improved prevention strategies and tailored interventions, ultimately helping alleviate the impact.
