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Stanciu BI, Iojiban M, Morariu-Barb A, Caraiani C, Procopet B, Stefanescu H, Lupsor-Platon M. Hepatic enhancement and signal intensity analysis on magnetic resonance imaging as prognostic biomarkers in advanced chronic liver disease. World J Hepatol 2025; 17(12): 111418 [PMID: 41479507 DOI: 10.4254/wjh.v17.i12.111418]
Bogdan-Ioan Stanciu, Marcela Iojiban, Andreea Morariu-Barb, Cosmin Caraiani, Monica Lupsor-Platon, Department of Radiology and Medical Imaging, “Iuliu Hațieganu” University of Medicine and Pharmacy, Cluj-Napoca 400012, Cluj, Romania
Bogdan Procopet, The Third Medical Clinic, Gastroenterology Department, “Iuliu Hațieganu” University of Medicine and Pharmacy, Cluj-Napoca 400012, Cluj, Romania
Bogdan Procopet, Horia Stefanescu, Department of Hepatology, “Octavian Fodor” Regional Institute of Gastroenterology and Hepatology, Cluj-Napoca 400162, Cluj, Romania
Monica Lupsor-Platon, Department of Medical Imaging, “Octavian Fodor” Regional Institute of Gastroenterology and Hepatology, Cluj-Napoca 400162, Cluj, Romania
Author contributions: Stanciu BI, Caraiani C, and Lupsor-Platon M conceptualized and designed the study; Stanciu BI, Iojiban M, and Morariu-Barb A collected and analyzed the data; Stanciu BI, Iojiban M, Morariu-Barb A, and Lupsor-Platon M contributed to the interpretation of the results; Stanciu BI drafted the manuscript; All authors contributed to the review and editing.
Institutional review board statement: The study was reviewed and approved by the Institutional Ethics Committee, No. 238/2025.
Informed consent statement: Signed informed consent was obtained from all participants.
Conflict-of-interest statement: The authors have no conflicts of interest to declare.
STROBE statement: The authors have read the STROBE Statement-checklist of items, and the manuscript was prepared and revised according to the STROBE Statement-checklist of items.
Corresponding author: Monica Lupsor-Platon, MD, PhD, Professor, Radiology and Medical Imaging, “Iuliu Hațieganu” University of Medicine and Pharmacy, Str. Victor Babeş No. 8, Cluj-Napoca 400012, Cluj, Romania. monica.lupsor@umfcluj.ro
Received: July 1, 2025 Revised: September 1, 2025 Accepted: November 5, 2025 Published online: December 27, 2025 Processing time: 180 Days and 14.9 Hours
Core Tip
Core Tip: This study investigated whether quantitative gadoxetate-enhanced magnetic resonance imaging can enhance prognostic assessment in patients with advanced chronic liver disease. Among 100 patients, hepatic enhancement (HE) and signal intensity were measured segmentally and globally. Global HE correlated strongly with Functional Liver Imaging Score, clinicobiological scores, liver stiffness, and portal pressure. Notably, lower HE independently predicted hepatic decompensation and mortality, demonstrating good diagnostic accuracy. These results suggest that HE provides an objective and reproducible biomarker that may complement conventional scoring systems, facilitating the earlier identification of high-risk patients and supporting personalized management strategies in clinical hepatology.
