Observational Study
Copyright ©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Hepatol. Jan 27, 2024; 16(1): 54-64
Published online Jan 27, 2024. doi: 10.4254/wjh.v16.i1.54
Metabolic puzzle: Exploring liver fibrosis differences in Asian metabolic-associated fatty liver disease subtypes
Sabhita Shabir Shaikh, Fakhar Ali Qazi-Arisar, Saba Nafay, Sidra Zaheer, Hafeezullah Shaikh, Zahid Azam
Sabhita Shabir Shaikh, Fakhar Ali Qazi-Arisar, Saba Nafay, Hafeezullah Shaikh, Zahid Azam, National Institute of Liver and GI Diseases, Dow University of Health Sciences, Sindh, Karachi 75330, Pakistan
Sidra Zaheer, School of Public Health, Dow University of Health Sciences, Sindh, Karachi 75330, Pakistan
Author contributions: Shaikh SS designed the research study; Shaikh SS and Nafay S participated in the data acquisition; Shaikh SS and Zaheer S participated in the analysis and interpretation of the data; Shaikh SS and Qazi-Arisar FA drafted the initial manuscript; Qazi-Arisar FA, Shaikh H, and Azam Z revised the article critically for important intellectual content.
Institutional review board statement: The study was reviewed and approved by the Dow University of Health Sciences Institutional Review Board (IRB-1842).
Informed consent statement: All study participants, or their legal guardian, provided informed written consent prior to study enrollment.
Conflict-of-interest statement: There are no conflicts of interest to report.
Data sharing statement: No additional data are available.
STROBE statement: The authors have read the STROBE Statement-checklist of items, and the manuscript was prepared and revised according to the STROBE Statement-checklist of items.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Fakhar Ali Qazi-Arisar, FACP, FCPS, FRCP, MBBS, MRCP, Assistant Professor, National Institute of Liver and GI Diseases, Dow University of Health Sciences, Suparco Road, Gulzar-e-Hijri, Scheme 33, Sindh, Karachi 75330, Pakistan. fakhar.arisar@gmail.com
Received: October 2, 2023
Peer-review started: October 2, 2023
First decision: October 9, 2023
Revised: October 22, 2023
Accepted: December 18, 2023
Article in press: December 18, 2023
Published online: January 27, 2024
Core Tip

Core Tip: This is the first study on the South-Asian population on assessment of fibrosis among metabolic-associated fatty liver disease (MAFLD) patients. The study highlights that as the number of risk factors increases in a patient with MAFLD, it is more likely to have progression of liver fibrosis.