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World J Hepatol. May 27, 2023; 15(5): 675-687
Published online May 27, 2023. doi: 10.4254/wjh.v15.i5.675
Current guidelines for diagnosis and management of hepatic involvement in hereditary hemorrhagic teleangiectasia
Luca Ielasi, Matteo Tonnini, Fabio Piscaglia, Ilaria Serio
Luca Ielasi, Matteo Tonnini, Fabio Piscaglia, Department of Medical and Surgical Sciences, University of Bologna, Bologna 40138, Italy
Luca Ielasi, Department of Internal Medicine, Ospedale per gli Infermi di Faenza, Faenza 48018, Italy
Matteo Tonnini, Fabio Piscaglia, Ilaria Serio, Division of Internal Medicine, Hepatobiliary and Immunoallergic Diseases, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna 40138, Italy
Author contributions: Ielasi L and Tonnini M conceived the manuscript, reviewed the literature and wrote the original draft; Serio I reviewed and edited the manuscript; Piscaglia F supervised; all authors read and agreed to the published version of the manuscript.
Conflict-of-interest statement: All authors declare no conflict of interest.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See:
Corresponding author: Luca Ielasi, MD, Doctor, Department of Medical and Surgical Sciences, University of Bologna, Via Albertoni, 15, Bologna 40138, Italy.
Received: February 7, 2023
Peer-review started: February 7, 2023
First decision: March 22, 2023
Revised: April 4, 2023
Accepted: April 12, 2023
Article in press: April 12, 2023
Published online: May 27, 2023
Core Tip

Core Tip: Hereditary hemorrhagic teleangiectasia (HHT) is the most common cause of hepatic vascular malformation in adults. Although liver involvement is common in HHT, most patients do not present any hepatic-related symptoms. Unfortunately, some patients have severe forms of disease with refractory medical conditions related to the hepatic vascular malformations. For those patients the only definitive treatment available at present is liver transplantation.