Systematic Reviews
Copyright ©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Hepatol. Dec 27, 2022; 14(12): 2025-2043
Published online Dec 27, 2022. doi: 10.4254/wjh.v14.i12.2025
CLIF-SOFA and CLIF-C scores for the prognostication of acute-on-chronic liver failure and acute decompensation of cirrhosis: A systematic review
Ebrahim Rashed, Jonathan Soldera
Ebrahim Rashed, Jonathan Soldera, Acute Medicine, University of South Wales, Cardiff CF37 1DL, United Kingdom
Author contributions: Both authors contributed to writing and reviewing the final draft of the manuscript.
Conflict-of-interest statement: All the authors declare no conflict of interest.
PRISMA 2009 Checklist statement: PRISMA 2009 was observed, and a PRISMA figure is included in the manuscript.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See:
Corresponding author: Jonathan Soldera, MD, MSc, Associate Professor, Staff Physician, Acute Medicine, University of South Wales, Llantwit Rd, Pontypridd, Cardiff CF37 1DL, United Kingdom.
Received: August 26, 2022
Peer-review started: August 26, 2022
First decision: October 11, 2022
Revised: October 18, 2022
Accepted: November 7, 2022
Article in press: November 7, 2022
Published online: December 27, 2022
Core Tip

Core Tip: Acute-on-chronic liver failure (ACLF) is a serious medical challenge worldwide, and its occurrence is a difficult clinical incident due to its severe presentation, quick disease course, and elevated short-term mortality. The European Association for the Study of Liver-Chronic-Liver Failure (EASL-CLIF) Consortium proposal has gained considerable acceptance as a diagnostic criteria for ACLF. CLIF-SOFA has increased the ability to detect patients with ACLF. Unless presenting with renal impairment and/or mild to moderate hepatic encephalopathy, cirrhotic patients with acute decompensation and single liver failure (or any other single "non-renal" organ failure) had a minimum mortality risk. These results suggest that CLIF-SOFA score surpasses other models in predicting mortality in ACLF patients, especially in the short-term.