Published online May 27, 2021. doi: 10.4254/wjh.v13.i5.522
Peer-review started: March 7, 2021
First decision: March 29, 2021
Revised: March 30, 2021
Accepted: April 29, 2021
Article in press: April 29, 2021
Published online: May 27, 2021
Core Tip: Liver involvement in coronavirus disease 2019 (COVID-19) is caused by either viral cytotoxicity or secondary to systemic immune dysregulation. Patients with pre-existing liver disease are at high risk of disease progression, morbidity, and mortality. Chronic liver disease with COVID-19 should be managed as per the standard guidelines, with education on hand hygiene, social distancing, and face masks to reduce hospital admissions. There is no evidence that currently available vaccines for severe acute respiratory syndrome coronavirus 2 will have any complications different from other inactivated vaccines and are recommended for patients with pre-existing liver disease, hepatocellular carcinoma, or liver transplant recipients.